Absolute Configuration of Migrastatin, a Novel 14-Membered Ring Macrolide.
نویسندگان
چکیده
منابع مشابه
Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells.
migrastatin isolate contained teleocidin-related compounds which display strong inhibitory activity against tumor cell migration. In this report, we describe the effects of teleocidin-free migrastatin on tumor cell migration and on the growth of several types of tumor cells. Whenthe original migrastatin sample was subjected to HPLC (Capcell Pak C18 column, 20X250mm) developing with 70% aq aceto...
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[reaction: see text] A novel ring opening ring closing metathesis (ROM-RCM) was demonstrated for cyclic conjugated dienes, effecting the excision of a C(2)H(2) unit and a net ring contraction. Applying the ring contraction metathesis, new 14-membered ring macrolide antibiotics were synthesized in a single step from existing 16-membered ring macrolides. This new class of macrolide antibiotics wi...
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Sir: The structure of the first l8-membered lactone, borrelidin, was described in 1967 by KELLERSCHIERLEIN1). In recent years, four more antibiotics have been added to this class. Concanamycins A, B and C2.3), produced by Streptomyces diastatochromogenes S45, inhibit the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. The fourth antibiotic, virustomycin A4,5) also produ...
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We studied the efficacy of the long-term administration of 14-membered ring macrolides in treating patients with diffuse panbronchiolitis (DPB) (34 patients) and bronchiectasis (BE) (40 patients). Oral administration of erythromycin (400 or 600 mg), roxithromycin (150 or 300 mg) or clarithromycin (200 or 400 mg) given daily for at least 2 months, was evaluated. The efficacy of erythromycin, rox...
متن کاملEffect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships.
significantly by long-term and low-dose treatment of 14memberedring macrolide antibiotics such as erythromycin (EM), clarithromycin (CAM) and roxithromycin (RXM)3'4). Anti-inflammatory mechanisms of macrolide antibiotics include the down-regulation of inflammatory cytokines and lymphocytes. EM and azithromycin (AZM), a 15memberedring macrolide antibiotic that has clinical effect in the treatmen...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2002
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.55.442